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Abstract Title:

Cardioprotective action of chia (Salvia hispanica L.) in ovariectomized rats fed a high fat diet.

Abstract Source:

Food Funct. 2021 Apr 7 ;12(7):3069-3082. Epub 2021 Mar 15. PMID: 33720242

Abstract Author(s):

Marcella Duarte Villas Mishima, Luiz Carlos Maia Ladeira, Bárbara Pereira da Silva, Renata Celi Lopes Toledo, Thomás Valente de Oliveira, Neuza Maria Brunoro Costa, Hércia Stampini Duarte Martino

Article Affiliation:

Marcella Duarte Villas Mishima

Abstract:

The reduction in estrogen levels is associated with the increased risk factors for cardiovascular disease development. The present study aimed to evaluate the effect of chia consumption in a standard diet (SD) or high fat diet (HFD) on ovariectomized (OVX) and non-ovariectomized (SHAM) rats, in relation to biometric measurements, oxidative stress, mineral content and ATPase enzymes in the heart. The study was conducted with 80 female Wistar rats, which received a SD or HFD for 18 weeks. During the first 7 weeks, the animals received the SD or HFD. Then, 40 rats were ovariectomized and 40 rats were SHAM operated. After recovery from surgery, the animals were allocated to 8 groups (n = 10) and they received one of the following diets for 8 weeks: SD, SD + chia, HFD and HFD + chia. In the OVX group, HFD increased weight gain, adiposity, cardiac hypertrophy, and nitric oxide (NO) and K concentration and decreased the Na/KATPase activity. In combination with HFD, ovariectomy decreased the catalase activity, Mg, Cu and Zn concentration, total ATPase activity, and Na/KATPase and Mg2 + ATPase activities; this group also presented higher NO, Ca, K, Fe and Mn concentration in the heart. The SHAM group fed chia presented a lower fat content in the heart. In the OVX group fed HFD, chia increased the activity of superoxide dismutase, decreased NO and maintained the content of minerals and ATPase enzymes. Thus, chia improved the biometric parameters of the heart, the antioxidant activity and maintained the content of minerals and ATPase enzymes, showing a cardioprotective action, but without reversing the deleterious effects of ovariectomy.

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