Abstract Title:

Inhibition of HIV-1 reverse transcriptase and HIV-1 replication by Calophyllum coumarins and xanthones.

Abstract Source:

Planta Med. 2002 Jan;68(1):86-7. PMID: 11842340

Abstract Author(s):

H R W Dharmaratne, G T Tan, G P K Marasinghe, J M Pezzuto

Article Affiliation:

1 Natural Products Programme, Institute of Fundamental Studies, Kandy, Sri Lanka. hrwd13@hotmail.com


As part of our continuing study on the Calophyllum species, a number of coumarins, xanthones and chromene acids from different Calophyllum species of Sri Lanka were tested for inhibitory activity against the HIV-1 and its virally-encoded reverse transcriptase (RT). These compounds were found to be inactive in both the HIV-1 RT and whole virus systems. In contrast, cordatolide A and B demonstrated IC(50) values of 19.3 and 11.7 microM, respectively, against HIV-1 replication in a novel green fluorescent protein (GFP)-based reporter cell assay (HOG.R5).

Study Type : In Vitro Study

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