Article Publish Status: FREE
Abstract Title:

The effect ofversus metronidazole on bacterial vaginosis in women: A double-blind randomized controlled trial.

Abstract Source:

J Adv Pharm Technol Res. 2018 Jan-Mar;9(1):15-19. PMID: 29441319

Abstract Author(s):

Zahra Pazhohideh, Solmaz Mohammadi, Nosrat Bahrami, Faraz Mojab, Parvin Abedi, Elham Maraghi

Article Affiliation:

Zahra Pazhohideh


Bacterial vaginosis (BV) is a common disorder among women of reproductive age. This study aimed to compare the effect of aextract-based cream and metronidazole on BV among women of reproductive age. In this study, 80 women of reproductive age with BV were randomly assigned to the(= 40) or metronidazole (= 40). Diagnosis of BV was confirmed when at least 3 of the 4 Amsel criteria were met (pH>4.5, whitish grey or thin homogeneous discharge, release of a fishy odor on adding 10% KOH, and detection of clue cells on microscopic examination). For each group, either a methanol extract ofor metronidazole vaginal cream (5 g) was used for 1 week intravaginally, and all signs and symptoms were assessed 1 week after treatment completion. Before the intervention, the two groups did not differ significantly with regard to vaginal burning, odor, dysuria, and dyspareunia, but itching was significantly more common in thegroup than in the metronidazole group (22.5% vs. 2.5%,= 0.01). One week after the intervention, all women in both groups were free of symptoms, including vaginal itching and burning sensation, odor, dysuria, and dyspareunia. None of the women in either group suffered any side effects fromor metronidazole.was effective for the treatment of BV in women of reproductive age, without any side effects. This herb could be recommended for women of reproductive age who uncomfortable with the potential side effects of synthetic drugs.

Study Type : Human Study

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