Abstract Title:

A double-blind randomized trial demonstrates the role of zonal priming&direct topical application of epigallocatechin-3-gallate in modulation of cutaneous scarring in human skin.

Abstract Source:

J Invest Dermatol. 2019 Feb 26. Epub 2019 Feb 26. PMID: 30822414

Abstract Author(s):

S Ud-Din, P Foden, M Mazhari, S Al-Habba, M Baguneid, S Bulfone-Paus, D McGeorge, A Bayat

Article Affiliation:

S Ud-Din


BACKGROUND: Epigallocatechin-3-gallate (EGCG), a polyphenol, influences cutaneous wound healing due to its anti-angiogenic, anti-inflammatory and anti-oxidant properties. We previously demonstrated the role of EGCG in scarring in ex vivo human scar models. Here, we evaluate direct application of topical EGCG compared with zonal-priming, a unique concept in immediate treatment of zone-of-injury at the time of wounding prior to scar formation.

TRIAL DESIGN: A double-blind randomised-controlled trial.

METHODS: We assessed EGCG application compared to placebo over 1-6 weeks, in scars created in 62 human volunteers using quantitative non-invasive devices, immunohistochemical analysis, mRNA sequencing and QRT-PCR of tissue-biopsies.

RESULTS: EGCG reduced mast cells at weeks 1-3 evidenced by gene and protein analyses (p≤0.01). M2 macrophages were increased with EGCG compared to placebo. EGCG application by zonal-priming significantly downregulated VEGFA and CD31 at week 1 and 2-4 weeks after direct application (p≤0.01). Direct EGCG application also reduced scar thickness at weeks 1-3 (p=0.001), and increased scar elasticity at week 4 (p=0.01). Increased hydration was evident both non-invasively and by increased hyaluronic acid (p<0.01) at week 3.

CONCLUSIONS: We demonstrate the beneficial role of both zonal priming and direct EGCG application in scar therapy with positive effect on scar thickness, erythema, hydration and elasticity.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.