Abstract Title:

Effect of black-currant extract on negative lens-induced ocular growth in chicks.

Abstract Source:

Ophthalmic Res. 2010 ;44(4):242-50. Epub 2010 Aug 10. PMID: 20699628

Abstract Author(s):

Hiroyuki Iida, Yuko Nakamura, Hitoshi Matsumoto, Yasuo Takeuchi, Shokichi Harano, Mamoru Ishihara, Osamu Katsumi

Article Affiliation:

Food and Health R&D Laboratories, Meiji Seika Kaisha Ltd., Sakado, Japan. hiroyuki_iida@meiji.co.jp


AIM: To evaluate the effects of orally administered black-currant (BC) extract on the enlargement of globe component dimensions induced in chicks by wearing negative lenses.

METHODS: Negative lenses (-8 D) were worn on the right eyes by 8-day-old chicks, and their fellow eyes acted as controls. BC extract and distilled water (vehicle control) were orally administered once a day for 3 days. To confirm the effect of BC anthocyanins (BCAs), they were intravenously administered once a day for 3 days. Dimensions of globe components of right eyes and fellow eyes were measured with an A-scan ultrasound instrument on the third day (day 4) after placement of the negative lenses.

RESULTS: Orally administered BC extract significantly inhibited enlargement of vitreous-chamber depth, axial and ocular lengths in a dose-dependent manner when compared to controls. Intravenously administered BCAs also inhibited elongation of vitreous-chamber depth and axial length when compared to controls.

CONCLUSIONS: This is the first evidence that BC extract and BCAs could inhibit enlargement of globe component dimensions in a negative lens-induced chick myopia model.

Study Type : Animal Study
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