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Article Publish Status: FREE
Abstract Title:

BioflavonoidSuppresses Hypertrophic Scar Formation by the TGF-/Smad Signaling Pathway.

Abstract Source:

Evid Based Complement Alternat Med. 2021 ;2021:2444839. Epub 2021 Sep 4. PMID: 34518767

Abstract Author(s):

Zha Ru, Ying Hu, Shenghua Huang, Li Bai, Kun Zhang, Yue Li

Article Affiliation:

Zha Ru

Abstract:

Background: Hypertrophic scar (HS) is a benign fibroproliferative skin disease resulting from an aberrant wound healing process and can cause aesthetic and functional damage to patients. Currently, there is no ideal treatment to treat this disease., a natural active bioflavonoid compound, is suggested to inhibit fibrosis and proliferation in certain cells.

Methods: In this study, we foundcould attenuate abnormal scar formation in an HS rabbit ear model. Additionally, the HE staining showsreduced scar elevation index (SEI) and Masson's trichrome staining changed collagen deposition.

Results: The expressions of type I collagen, type III collagen, and TGF-1 were much lower under a proper dose oftreatment, and Smad7 expression was also enhanced, which are examined by real-time PCR, immunohistochemistry, and western blot.

Conclusion: Our data indicated thatcan alleviate dermal scarring via the TGF-/Smad signaling pathway probably by upregulating Smad 7 expression and, thus, suppressing the expression of type I and type III collagens and TGF-1.

Study Type : In Vitro Study

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Sayer Ji
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