Abstract Title:

Bioassay-Guided Isolation of an Abetiane-Type Diterpenoid fromThat Protects against Concanavalin A-Induced Autoimmune Hepatitis.

Abstract Source:

J Nat Prod. 2021 08 27 ;84(8):2189-2199. Epub 2021 Aug 12. PMID: 34383500

Abstract Author(s):

Yunfang Cao, Xiaosheng Tan, Ali Adhab Al Chnani, Pengkun Li, Zhengyi Shi, Hao Feng, Lingjuan Sun, Qiangbing Xia, Xi Yang, Yulin Duan, Yi Guo, Gang Chen, Changxing Qi, Yonghui Zhang

Article Affiliation:

Yunfang Cao


is a widely used edible Chinese medicinal plant. In the present study, two new abietane-type diterpenoids, abietoquinones A () and B (), were isolated from this plant by an immunosuppressive bioassay-guided isolation procedure. Their structures were elucidated unambiguously by NMR spectroscopic analysis, single-crystal X-ray crystallography, and electronic circular dichroism calculations. Compoundsandbear a cyclohex-2-ene-1,4-dione moiety, which is uncommon among abietane diterpenes. Also, abietoquinone A () suppressed murine splenocyte proliferation and decreased the production of proinflammatory cytokines induced by concanavalin A (Con A) in vitro. In Con A-challenged mice, preinjection withsignificantly ameliorated liver injury. Additionally, abietoquinone A () exhibited inhibitory activities against the proliferation of murine splenocytes and human T cells induced by anti-CD3/anti-CD28 monoclonal antibodies (mAbs).

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