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Article Publish Status: FREE
Abstract Title:

Berbamine and thymoquinone exert protective effects against immune-mediated liver injuryNF-κB dependent pathway.

Abstract Source:

Front Vet Sci. 2022 ;9:960981. Epub 2022 Jul 26. PMID: 35958317

Abstract Author(s):

Sarmed H Kathem, Waleed K Abdulsahib, Munaf H Zalzala

Article Affiliation:

Sarmed H Kathem

Abstract:

Background: Immune-mediated hepatitis is a severe impendence to human health, and no effective treatment is currently available. Therefore, new, safe, low-cost therapies are desperately required. Berbamine (BE), a natural substance obtained primarily fromL, is a traditional herbal medicine with several bioactivities, such as antimicrobial and anticancer activities. Thymoquinone (TQ), a phytochemical molecule derived from theplant's black cumin seeds, has attracted interest owing to itsanti-inflammatory, antioxidant, and anticancer properties.

Aim: This current study's aims was to examine the protective impacts of BE and TQ in Concanavalin A (ConA)- induced acute liver injury and the action's underlying mechanism.

Methods: sixty mice of both sexes were used and divided into four groups (each group with six mice) as follows: Group I obtained distilled water (negative control group). Group II received distilled water with a single dose of 0.1 ml ConA (20 mg/kg) on day 4 by retro-orbital route (model group). Groups III and IV received BE (30 mg/kg/day) and TQ (25 mg/kg/day), respectively, by oral gavage for four successive days, with a single dose of ConA (20 mg/kg) on day 4, then all animals were sacrificed after 8 h and prepared for liver and blood collection.

Results: ConA administration increased the ALT, AST, TNF-α, INFγ, and NF-κB significantly (<0.001) in the model group. Both BE and TQ could reduce these parameters significantly (<0.001) in groups III and IV, respectively, compared to the model group.

Conclusion: Both BE and TQ prominently attenuated ConA immune-mediated liver injury. These findings give a remarkable insight into developing a new therapeutic agent for treating hepatitis and other autoimmune diseases.

Study Type : Animal Study

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