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Article Publish Status: FREE
Abstract Title:

Autopsy Histopathologic Cardiac Findings in Two Adolescents Following the Second COVID-19 Vaccine Dose.

Abstract Source:

Arch Pathol Lab Med. 2022 Feb 14. Epub 2022 Feb 14. PMID: 35157759

Abstract Author(s):

James R Gill, Randy Tashjian, Emily Duncanson

Article Affiliation:

James R Gill

Abstract:

CONTEXT: - Myocarditis in adolescents has been diagnosed clinically following the administration of the second dose of an mRNA vaccine for coronavirus disease 2019 (COVID-19).

OBJECTIVE: - To examine the autopsy microscopic cardiac findings in adolescent deaths that occurred shortly following administration of the second Pfizer-BioNTech COVID-19 dose to determine if the "myocarditis" described in these instances has the typical histopathology of myocarditis.

DESIGN: - Clinical and autopsy investigation of two teenage boys who died shortly following administration of the second Pfizer-BioNTech COVID-19 dose.

RESULTS: - The microscopic examination revealed features resembling a catecholamine-induced injury, not typical myocarditis pathology.

CONCLUSIONS: - The myocardial injury seen in these post-vaccine hearts is different from typical myocarditis and has an appearance most closely resembling a catecholamine-mediated stress (toxic) cardiomyopathy. Understanding that these instances are different from typical myocarditis and that cytokine storm has a known feedback loop with catecholamines may help guide screening and therapy.

Study Type : Human: Case Report

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Sayer Ji
Founder of GreenMedInfo.com

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