Abstract Title:

Astaxanthin supplementation reduces dichlorvos-induced cytotoxicity in.

Abstract Source:

3 Biotech. 2019 Mar ;9(3):88. Epub 2019 Feb 15. PMID: 30800599

Abstract Author(s):

S J Sudharshan, Subasri Subramaniyan, Greeshma Satheeshan, Madhu Dyavaiah

Article Affiliation:

S J Sudharshan


This study evaluates the protective effect of astaxanthin against dichlorvos cytotoxicity in yeast. Dichlorvos induce a dose-dependent cytotoxicity in yeast cells, which is mediated by oxidative stress. Our experimental results showed pre-treatment with astaxanthin enhances cell viability by 20-30% in yeast cells exposed to dichlorvos. A decrease in DCF fluorescence intensity and lipid peroxidation, increased SOD activity, and glutathione levels in astaxanthin-treated cells indicate that astaxanthin protected the cells against dichlorvos-induced oxidative stress. Reduced chromatin condensation and nuclear fragmentation in astaxanthin pre-treated cells also indicate that astaxanthin rescued the cells from dichlorvos-induced apoptosis. Our overall results suggest that dichlorvos induces oxidative stress-mediated cytotoxicity in yeast cells, and that was rescued by astaxanthin pre-treatment.

Study Type : Animal Study

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