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Article Publish Status: FREE
Abstract Title:

Assessment of the Cytotoxic Activity of Triphala: A Semisolid Traditional Formulation on HepGCancer Cell Line.

Abstract Source:

Biomed Res Int. 2021 ;2021:6689568. Epub 2021 Aug 11. PMID: 34471640

Abstract Author(s):

Ali Sahragard, Zohreh Alavi, Zohreh Abolhassanzadeh, Mahmoodreza Moein, Afshin Mohammadi-Bardbori, Mahmoud Omidi, Mohammad M Zarshenas

Article Affiliation:

Ali Sahragard

Abstract:

Cancer chemotherapies may result in resistance, and therefore, contemporary treatments including natural products may find an increasing consideration. As per Persian medicine (PM), many natural products have been used for malignant and chronic diseases. Triphala, with a combination ofRetz.,Retz.,L., and honey, is a multi-ingredient traditional formulation attributed to anticancer activities in PM. This study is aimed at evaluating the cytotoxic activity of this preparation on HepG, the human liver cancer cell line. Hydroalcoholic extracts were prepared from the formulation and its components. Compared with the control and Cisplatin, the extracts were tested using MTT assay at different concentrations. All concentrations of the preparation, as well as Cisplatin, were effective significantly against HepGcells. All extract preparations at multiple concentrations were significantly effective as evidenced by MTT assay when compared to the control group. The IClevel for Triphala extract was 77.63± 4.3 g/ml. Based on the results, Triphala and its components have cytotoxic activity on the HepGcancer cell line and they can reduce the survival rate significantly.

Study Type : In Vitro Study

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