Abstract Title:

Action of Matricaria recutita (chamomile) in the management of radiochemotherapy oral mucositis: A systematic review.

Abstract Source:

Phytother Res. 2022 Mar ;36(3):1115-1125. Epub 2022 Feb 7. PMID: 35129844

Abstract Author(s):

Juliana Borges de Lima Dantas, Tila Fortuna Costa Freire, Ana Carla Barletta Sanches, Erielma Lomba Dias Julião, Alena Ribeiro Alves Peixoto Medrado, Gabriela Botelho Martins

Article Affiliation:

Juliana Borges de Lima Dantas


The objective of this study was to evaluate the effect of topical chamomile in the prevention and/or treatment of oral mucositis (OM) in cancer patients. It was a systematic review, which sought articles of the randomized clinical trial according to the PRISMA parameters, registered in the PROSPERO. The databases used were PubMed, Cochrane Library, and Bireme. Descriptors were selected from DeCs/MeSH and the PICO strategy was applied. The search found 148 publications. After all the steps, six articles were selected. The total sample included 492 patients and all studies used the same OM measurement scale. The results showed that the application of topical chamomile was effective in the prevention and/or treatment of OM in four of the six studies, with a dose ranging from 1% to 2.5% and duration that ranged from single to 4 times a day. Some limitations were observed: the minimum age of the patients was not informed, and there was no specification of the sites involved or the chemotherapies used. The application of topical chamomile in the preventive/therapeutic of chemo-induced OM seems to be recommended. In addition, scientific production should be encouraged, as it aims to determine useful protocols for this phytotherapy for the oncology population.

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Sayer Ji
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