Abstract Title:

Antiviral activity of seed extract from Citrus bergamia towards human retroviruses.

Abstract Source:

Bioorg Med Chem. 2011 Mar 15 ;19(6):2084-9. Epub 2011 Jan 26. PMID: 21334901

Abstract Author(s):

Emanuela Balestrieri, Francesco Pizzimenti, Angelo Ferlazzo, Salvatore V Giofrè, Daniela Iannazzo, Anna Piperno, Roberto Romeo, Maria Assunta Chiacchio, Antonio Mastino, Beatrice Macchi

Article Affiliation:

Emanuela Balestrieri


The effects of an extract from Citrus bergamia (BSext) and those of two products purified from the same extract, that is, nomilin and limonin, and reference compounds, towards HTLV-1 have been reported. Moreover, they were also compared with those obtained towards HIV-1. Results showed that the efficacy of both BSext and limonin in inhibiting HTLV-1 as well as HIV-1 expression in infected cells, as evaluated by comparable quantitative assays, was close to that of the effective, reference compounds, respectively. The protective effect of BSext and of the purified products was associated with the inhibition of both HTLV-1 and HIV-1 RT activities in conceptually similar, cell-free assays. The cytotoxicity of the assayed compounds of natural origin was substantially less pronounced than that of the reference compounds, thus showing a favourable selectivity index for the novel BSext product.

Study Type : In Vitro Study

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