Article Publish Status: FREE
Abstract Title:

Antispasmodic Activity of Prenylated Phenolic Compounds from the Root Bark of.

Abstract Source:

Molecules. 2019 Jul 8 ;24(13). Epub 2019 Jul 8. PMID: 31288489

Abstract Author(s):

Zoofishan Zoofishan, Norbert Kúsz, Attila Csorba, Gábor Tóth, Judit Hajagos-Tóth, Anna Kothencz, Róbert Gáspár, Attila Hunyadi

Article Affiliation:

Zoofishan Zoofishan


Black mulberry is a widely acknowledged ancient traditional medicine. Its extract and constituents have been reported to exert various bioactivities including antimicrobial, hypotensive, analgesic etc. effects. While black mulberry preparations are also used as antispasmodic agents in folk medicine, no related studies are available on its isolated constituents. Through an extensive chromatographic purification, seven phenolic compounds were isolated from the methanol extract ofroot bark, including morusin (), kuwanon U (), kuwanon E (), moracin P (), moracin O (), albanol A (), and albanol B (). A complete NMR signal assignment of moracin P and O was achieved, and related literature errors confusing the identity of moracin derivatives are hereby clarified. Compounds,andwere identified as strong antispasmodic agents on isolated rat ileum and tracheal smooth muscles, while compound, a methoxy derivative of, was inactive. Moracin O () inhibited the ileal and tracheal smooth muscle contractions with Evalues of 85% and 302 mg, respectively. Those actions were superior as compared with papaverine. Our findings demonstrate that prenylated arylbenzofurans, geranylated flavonoids and Diels-Alder adducts fromare valuable antispasmodic agents. Compounds,andare suggested as marker compounds for quality control of antispasmodic mulberry preparations. Moracin O () is a new lead compound for related drug development initiatives.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Antispasmodic : CK(140) : AC(37)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.