Abstract Title:

Antioxidant vitamin levels in sickle cell disorders.

Abstract Source:

Natl Med J India. 2007 Jan-Feb;20(1):11-3. PMID: 17557515

Abstract Author(s):

Debes Ray, Pradeep Deshmukh, Kalyan Goswami, Neelam Garg

Article Affiliation:

Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442102, Maharashtra.


BACKGROUND: Sickle cell disorder is a haemoglobinopathy prevalent in the Vidharbha region of Maharashtra, central India. With recent evidence of oxidative stress in sickle haemoglobinopathy, a possible deficiency of antioxidant vitamins was suspected.

METHODS: We measured plasma vitamin E, vitamin C and beta-carotene levels in persons with heterozygous (n=80) and homozygous sickle cell state (n=20), and suitable healthy controls for these groups (n=100 and 66, respectively) in a community-based study in the villages near our institution.

RESULTS: Subjects with heterozygous sickle cell trait had lower vitamin E levels than their respective controls (p<0.05). Subjects with homozygous sickle cell disease had lower levels of all three vitamins (p<0.05). Vitamins E and C levels showed a significant positive correlation in both forms of sickle cell disorder.

CONCLUSION: Our findings suggest that there is depletion of the antioxidant vitamins, particularly in severe forms of sickle cell disorder. A trial of administration of therapeutic doses of vitamin E in this condition is warranted.

Study Type : Human Study

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Sayer Ji
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