Abstract Title:

Antimicrobial and quorum sensing inhibitory activities of the pericarp of Garcinia mangostana.

Abstract Source:

Pak J Pharm Sci. 2016 Jul ;29(4 Suppl):1353-7. PMID: 27592485

Abstract Author(s):

Hani Z Asfour

Article Affiliation:

Hani Z Asfour


A prenylated xanthone,α-mangostin was separated from the alcoholic extract of Garcinia mangostana pericarp. Its structure was established by different spectroscopic analysis. The total methanolic extract (TME) and different fractions of G. mangostana pericarp as well as α-mangostin were assessed for their antimicrobialand quorum sensing inhibitory effects (QSI). The TME, CHCl3 fraction, and α-mangostin exhibited strong activity against all tested strains. While, EtOAc, n-BuOH, and aqueous fractions showed moderate activity against some of the tested organisms. In addition TME, CHCl3, EtOAc, and α-mangostin showed promising QSI, while n-BuOH and aqueous fractions showed moderate activity. Minimal inhibitory concentration (MIC) for TME, CHCl3 fractions, and α-mangostin was also assessed.

Study Type : In Vitro Study

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