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Article Publish Status: FREE
Abstract Title:

Antileukaemic Cell Proliferation and Cytotoxic Activity of Edible Golden Cordyceps () Extracts.

Abstract Source:

Evid Based Complement Alternat Med. 2022 ;2022:5347718. Epub 2022 Apr 22. PMID: 35497915

Abstract Author(s):

Singkome Tima, Tawat Tapingkae, Chaiwat To-Anun, Parinn Noireung, Phikul Intaparn, Wantida Chaiyana, Jakkapan Sirithunyalug, Pawaret Panyajai, Natsima Viriyaadhammaa, Wariya Nirachonkul, Lapamas Rueankham, Win Lae Aung, Fah Chueahongthong, Sawitree Chiampanichayakul, Songyot Anuchapreeda

Article Affiliation:

Singkome Tima

Abstract:

Golden cordyceps () is a mushroom of the genus. It has been used as a food supplement for both healthy and ill people. In this study, the antileukaemic cell proliferation activities of golden cordyceps extracts were examined and compared with standard cordycepin (CDCP) in EoL-1, U937, and KG-1a cells. Wilms' tumour 1 (WT1) protein was used as a biomarker of leukaemic cell proliferation. The cytotoxicity of the extracts on leukaemic cells was determined using the MTT assay. Their inhibitory effects on WT1 protein expression and cell cycle progression of EoL-1 cells were investigated using Western blotting and flow cytometry, respectively. Induction of KG-1a cell differentiation (using CD11b as a marker) was determined using flow cytometry. The golden cordyceps extracts exhibited cytotoxic effects on leukaemic cells with the highest ICvalue of 16.5 ± 3.9 g/mL, while there was no effect on normal blood cells. The expression levels of WT1 protein in EoL-1 cells were decreased after treatment with the extracts. Moreover, cell cycle progression and cell proliferation were inhibited. The levels of CD11b increased slightly following the treatment. All these findings confirm the antileukaemic proliferation activity of golden cordyceps.

Study Type : In Vitro Study

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