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Article Publish Status: FREE
Abstract Title:

Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells.

Abstract Source:

Sci Rep. 2021 Jan 12 ;11(1):675. Epub 2021 Jan 12. PMID: 33436830

Abstract Author(s):

Tomoyuki Makino, Kouji Izumi, Kaoru Hiratsuka, Hiroshi Kano, Takashi Shimada, Taito Nakano, Suguru Kadomoto, Renato Naito, Hiroaki Iwamoto, Hiroshi Yaegashi, Kazuyoshi Shigehara, Yoshifumi Kadono, Hiroki Nakata, Yohei Saito, Kyoko Nakagawa-Goto, Norihiko Sakai, Yasunori Iwata, Takashi Wada, Atsushi Mizokami

Article Affiliation:

Tomoyuki Makino

Abstract:

Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, the multiple potential pharmacological actions of both have yet to be fully understood. This study therefore investigated the effects of kahweol acetate and cafestol on human renal cancer ACHN and Caki-1 cells. Accordingly, the combination of kahweol acetate and cafestol administration synergistically inhibited cell proliferation and migration by inducing apoptosis and inhibiting epithelial-mesenchymal transition. Mechanistic dissection revealed that kahweol acetate and cafestol inhibited Akt and ERK phosphorylation. Moreover, kahweol acetate and cafestol downregulated the expression of not only C-C chemokine receptors 2, 5, and 6 but also programmed death-ligand 1, indicating their effects on the tumor microenvironment. Thus, kahweol acetate and cafestol may be novel therapeutic candidates for renal cancer considering that they exert multiple pharmacological effects.

Study Type : In Vitro Study

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Sayer Ji
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