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Abstract Title:

Anti-malarial activity in a Chinese herbal supplement containing Inonotus obliquus and Panax notoginseng.

Abstract Source:

Parasitol Int. 2022 Apr ;87:102532. Epub 2021 Dec 18. PMID: 34933121

Abstract Author(s):

Takuro Endo, Yuki Nakagomi, Eri Kawaguchi, Eri Saki H Hayakawa, Hoai Nam Vu, Hitoshi Takemae, Yuta Shinohara, Da Yang, Tatsuya Usui, Tetsuya Mizutani, Yoichi Nakao, Tetsuya Furuya

Article Affiliation:

Takuro Endo

Abstract:

Plasmodium falciparum, the most virulent human malaria parasite, causes serious diseases among the infected patients in the world and is particularly important in African regions. Although artemisinin combination therapy is recommended by the WHO for treatment of P. falciparum-malaria, the emergence of artemisinin-resistant parasites has become a serious issue which underscores the importance of sustained efforts to obtain novel chemotherapeutic agents against malaria. As a part of such efforts, thirty-nine herbal extracts from traditional Chinese medicine (TCM) were assayed for their anti-malarial activity using 3D7 strain of P. falciparum. Three herbal supplements appeared to possess higher specific anti-malarial activity than the others. One of them (D3) was separated by two sequential fractionations with reverse-phase (the first step) and normal-phase (the second step) liquid chromatography, in which some fractions resulted in higher specific activities than those of D3 or the previous fractions. Cell toxicity assay was performed with the fractions of the first fractionation and demonstrated no obvious cell toxicity. These results suggest that structure determination of the major compound for the anti-malarial activity in D3 may help the development of more potent chemicals in the future.

Study Type : In Vitro Study

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