Abstract Title:

Anti-inflammatory activity of polysaccharides from Phellinus linteus by regulating the NF-κB translocation in LPS-stimulated RAW264.7 macrophages.

Abstract Source:

Int J Biol Macromol. 2019 May 15 ;129:61-67. Epub 2019 Feb 4. PMID: 30731160

Abstract Author(s):

Zhenglu Xie, Yang Wang, Juqing Huang, Ning Qian, Guozhi Shen, Linghua Chen

Article Affiliation:

Zhenglu Xie


Inflammatory response remains one of the most common and serious complications of disease. In order to profound understanding relationship between Phellinus linteus polysaccharides (TCM) and inflammation, inflammatory cell model was constructed by LPS acting RAW264.7 cell line. The results showed that TCM could decrease the pro-inflammatory cytokines (TNF-α, IL-1β, IL-2, IL-6 and IL-12) contents and the mRNA expression levels and increase the anti-inflammatory cytokines (IL-4 and IL-10) contents and the mRNA expression levels. Additionally, the levels of NF-κB translocation was significantly decreased, which associated with the IκBα phosphorylation level decreased and the AMPKα phosphorylation level increased. These results indicated that TCM could reduce the inflammatory responses in the LPS induced inflammatory cell model might be related to inhibit NF-κB translocation and regulate the balance of anti-inflammatory and pro-inflammatoryfactors.

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