Article Publish Status: FREE
Abstract Title:

Anti-Hyperuricemic and Uricosuric Potential ofin Oxonate-Induced Hyperuricemic Rats.

Abstract Source:

Dose Response. 2021 Jul-Sep;19(3):15593258211040329. Epub 2021 Sep 1. PMID: 34483784

Abstract Author(s):

Muhammad Bilal, Saeed Ahmad, Tayyeba Rehman, Aymen Owais Ghauri, Sana Khalid, Waheed Mumtaz Abbasi, Shahbaz Ahmad Zakki

Article Affiliation:

Muhammad Bilal


Hyperuricemia is a metabolic disorder with characteristic elevated serum uric acid. Recently, several plant-based medicines are being used for the treatment of hyperuricemia. The study aimed to find the hypouricemic potential ofinandstudy models. Instudies, xanthine oxidase inhibition assay was performed to evaluate ICvalue and capsule absorbance of the drug, respectively. Forexperiment, the study comprised 15 groups of rats.results revealed that significant xanthine oxidase inhibition was shown bywith an ICvalue of 272.73±.3 μg/mL. Similarly, oral administration ofwith dosages of 250 and 500 mg/kg decreased serum and liver uric acid levels significantly in a dose- and time-dependent manner in oxonate-induced hyperuricemic rats. Furthermore, 3-day and 7-day administration ofshowed more potential compared to 1-day administrations. The present study indicated marked hypouricemic effects ofin rats. Due to caveat of the small sample size, a firm assumption of the hypouricemic effect ofcannot be made. However, extensive study is needed to find out the exact molecular mechanism involved and to translate its effects into clinical trials for the further validation of the results.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Uricosuric Agents : CK(205) : AC(44)

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