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Article Publish Status: FREE
Abstract Title:

Andrographolide Suppresses Pyroptosis inMacrophages via the microRNA-155/Nrf2 Axis.

Abstract Source:

Oxid Med Cell Longev. 2022 ;2022:1885066. Epub 2022 Apr 28. PMID: 35528511

Abstract Author(s):

Yan Fu, Jingjing Shen, Fanglin Liu, Hemin Zhang, Yuejuan Zheng, Xin Jiang

Article Affiliation:

Yan Fu

Abstract:

Tuberculosis (TB) remains a leading threat to public health worldwide with(Mtb) infections causing long-term abnormal and excessive inflammatory responses, which in turn lead to lung damage and fibrosis, and ultimately death. Host-directed therapy (HDT) has been shown to be an effective anti-TB strategy in the absence of effective anti-TB drugs. Here, we used anmacrophage model of Mtb infection to evaluate the effects of andrographolide (Andro), extracted from, on pyroptosis in Mtb-infected macrophages. We evaluated the molecular mechanisms underlying these outcomes. These evaluations revealed that Andro downregulated the expression of proinflammatory miR-155-5p, which then promoted the expression of Nrf2 to suppress pyroptosis in Mtb-infected macrophages. Further study also demonstrated that siNrf2 could attenuate the inhibitory effect of Andro on TXNIP, validating our mechanistic studies. Thus, our data suggest that Andro may be a potential candidate adjuvant drug for anti-TB therapy as it inhibits pyroptosis in Mtb-infected macrophages, potentially improving clinical outcomes.

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