Abstract Title:

Measles Virus Neutralizing Antibodies in Intravenous Immunoglobulins: Is an Increase by Revaccination of Plasma Donors Possible?

Abstract Source:

J Infect Dis. 2017 11 15 ;216(8):977-980. PMID: 28968738

Abstract Author(s):

Jens Modrof, Björn Tille, Maria R Farcet, John McVey, Jessica A Schreiner, Charles M Borders, Maria Gudino, Peter Fitzgerald, Toby L Simon, Thomas R Kreil

Article Affiliation:

Jens Modrof


We report a screen of plasma donors confirming that widespread use of childhood measles vaccination since 1963 resulted in a decrease in average measles virus antibody titers among plasma donors, which is reflected in intravenous immunoglobulins (IVIGs). The measles virus antibody titer, however, is a potency requirement for IVIGs, as defined in a Food and Drug Administration regulation. To mitigate the decline in measles virus antibody titers in IVIGs and to ensure consistent product release, revaccination of plasma donors was investigated as a means to boost titers. However, revaccination-induced titer increases were only about 2-fold and short-lived.

Study Type : Human Study

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