Abstract Title:

α-Linolenic Fatty Acid Supplementation Decreases Tumor Growth and Cachexia Parameters in Walker 256 Tumor-Bearing Rats.

Abstract Source:

Nutr Cancer. 2015 May 26:1-8. Epub 2015 May 26. PMID: 26011096

Abstract Author(s):

Dalton Luiz Schiessel, Ricardo K Yamazaki, Marcelo Kryczyk, Isabela Coelho, Adriana A Yamaguchi, Daniele C T Pequito, Gleisson A P Brito, Gina Borghetti, Luiz C Fernandes

Article Affiliation:

Dalton Luiz Schiessel


Fish oil (FO) has been shown to affect cancer cachexia, tumor mass, and immunity cell. n-3 PUFA, specificallyα-linolenic fatty acid (ALA), has controversial effects. We investigated this in nontumor-bearing Wistar rats fed regular chow (C), fed regular chow and supplemented with FO or Oro Inca oil (OI), and Walker 256 tumor-bearing rats fed regular chow (W), fed regular chow and supplemented with FO (WFO)or OI (WOI). Rats were supplemented (1g/kg body weight/day) during 4 wk and then the groups tumor-bearing were inoculated with Walker 256 tumor cells suspension and 14 days later the animals were killed. WFO increased EPA fivefold and DHA 1.5-fold in the tumor tissue compared to W (P<0.05). OI supplementation increased of threefold of ALA when compared to W (P<0.05). Tumor mass in WFO and OI was of 2.3-fold lower, as well as tumor cell proliferation of 3.0-fold tumor tissue lipoperoxidation increased of 76.6% and cox-2 expression was 20% lower. Cachexia parameters were attenuate, blood glucose (25% higher), Triacylglycerolemia (50% lower), and plasma TNF-α (65% lower; P<0.05) and IL-6 (62.5% lower). OI, rich in ALA, caused the same effect on cancer as those seen in FO.

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