Article Publish Status: FREE
Abstract Title:

Anti-Leishmanial Activity (In Vitro and In Vivo) of Allicin and Allicin Cream Using Leishmania major (Sub-strain Zymowme LON4) and Balb/c Mice.

Abstract Source:

PLoS One. 2016 ;11(8):e0161296. Epub 2016 Aug 18. PMID: 27537199

Abstract Author(s):

Dina M Metwally, Ebtesam M Al-Olayan, Manal F El-Khadragy, Badriah Alkathiri

Article Affiliation:

Dina M Metwally


BACKGROUND: Leishmania is a unicellular protozoan parasite that produces several human diseases, ranging from localized self-healing cutaneous lesions to deadly visceral infections.

OBJECTIVE: The effect of allicin on the growth of Leishmania major (L. major) promastigotes was evaluated under in vitro conditions. Moreover, the efficacy of a topical allicin cream was examined in BALB/c (Bagg albino, laboratory-bred strain of the House Mouse) mice with cutaneous leishmanial lesions compared to the currently used drug, sodiumstibogluconate (pentostam).

METHODS: Cytotoxiciy and promastigote proliferation were measured. Different concentrations (50, 100, 150, and 200μM) of liquid allicin were tested on L. major promastigotes twice: after 24 and 48 hours using an MTT colorimetric assay. In the in vivo condition, the efficacies of allicin cream and liquid allicin at two concentrations (0.15 μM/mouse and 0.30 μM/mouse) were evaluated. Serum factors of the control and treated groups were tested to evaluate the toxic effects of allicin on the liver and kidney.

RESULTS: Allicin at a concentration of 50μM inhibited the growth of Leishmania promastigotes. Topical application of allicin cream reduced lesion sizes in mice. No significant differences in biochemical analysis were observed between the control and treated groups.

CONCLUSIONS: Allicin has antileishmanial effects under in vitro and in vivo conditions and may be used in clinical applications.

Study Type : Animal Study, In Vitro Study
Additional Links
Pharmacological Actions : Leishmanicidal : CK(118) : AC(79)
Additional Keywords : Allicin, Leishmaniasis, Leishmanicidal

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.