Abstract Title:

Negative effects of alcohol intake and estrogen deficiency combination on osseointegration in a rat model.

Abstract Source:

J Oral Implantol. 2011 Apr 19. Epub 2011 Apr 19. PMID: 21504361

Abstract Author(s):

Leonardo Marchini, Camila P de Deco, Adriana P Marchini, Mary Anne M Barbara, Luana M Vasconcellos, Rosilene F Rocha, Leonardo Marchini

Article Affiliation:

a University of Taubaté, Professor, Dentistry, Department of Biosciences and Oral Diagnosis, São José dos Campos School of Dentistry, São Paulo State University - UNESP, Brazil; Department of Dentistry, University of Taubaté; Faculty of Health Sciences, University of Vale do Paraíba.


Abstract Alcohol intake and estrogen deficiency can both affect bone physiology and have shown to have an adverse effect on dental implant therapy. However, the combination of both factors on osseointegration is unknown. The aim of this study was to evaluate osseointegration in rats fed with alcohol and presenting induced estrogen deficiency. Ninety-six female rats were divided according to diet and hormonal condition into six groups as follows: Group Sh-W: Sham (simulated ovariectomy) control, food and water ad libitum; Group Sh-Et: Sham, food and 20% ethanol solution ad libitum; Group Sh-Su: Sham, food and sucrose solution controlled to ensure an isocaloric diet in relation to Sh-Et ; Group Ov-W: ovariectomy, food and water ad libitum; Group Ov-Et: ovariectomy, food and 20% ethanol solution ad libitum; Group Ov-Su: ovariectomy, food and sucrose solution controlled to ensure an isocaloric diet as Ov-Et. The groups were subdivided according to time of euthanasia: 30 and 45 days after placement of implants. Implant surgery was performed one month after ovariectomy or Sham. After euthanasia, the femurs were removed and evaluated by histomorphometry. Groups Ov-Et and Ov-Su showed the lowest percentage of bone-to-implant contact. The combination of alcohol intake and estrogen deficiency, and the combination of estrogen deficiency and reduced ingestion of food can negatively affect osseointegration in rats.

Study Type : Animal Study

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