Abstract Title:


Abstract Source:

Retin Cases Brief Rep. 2018 Jul 25. Epub 2018 Jul 25. PMID: 30048403

Abstract Author(s):

Moreno Menghini, Vignesh Raja, Jeremy Raiter, Chandrakumar Balaratnasingam, Ian J Constable

Article Affiliation:

Moreno Menghini


PURPOSE: To report a case of Zostavax-associated acute retinal necrosis in a patient with chronic lymphocytic leukemia.

METHODS: Case report.

PATIENTS: A 76-year-old white man.

RESULTS: Unilateral acute retinal necrosis with obliterative angiopathy developed in close proximity of a Zostavax vaccine. Treatment with valacyclovir hydrochloride (1 g orally three times a day) and intravitreal ganciclovir (4 mg/0.1 mL) was initiated on presentation. Because of continuous increase of the retinal necrosis, patient was switched to intravenous acyclovir (7.5 mg/kg body weight, adapted to reduced glomerular filtration rate) and given intravitreal foscarnet (2.4 mg/0.1 mL). Despite being on maximal antiviral therapy, the patient suffered a central retinal artery occlusion.

DISCUSSION: Acute retinal necrosis is a severe complication and potentially blinding disease of herpes zoster, and can occur in association with herpes zoster immunization, in particular, in immune suppressed patients.

Study Type : Human: Case Report

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