Abstract Title:

Acute immune thrombocytopenic purpura as adverse reaction to oral polio vaccine (OPV).

Abstract Source:

Hum Vaccin Immunother. 2013 Jun 4 ;9(8). Epub 2013 Jun 4. PMID: 23807364

Abstract Author(s):

Cheng-Qiang Jin, Hai-Xin Dong, Zhuo-Xiang Sun, Jian-Wei Zhou, Cui-Yun Dou, Shu-Hua Lu, Rui-Rui Yang

Article Affiliation:

Clinical Laboratory Medicine Department; Attached Hospital of Jining Medical College; Shandong, Jining P.R. China.


A case of acute immune thrombocytopenic purpura following oral polio vaccine (OPV) is reported. An 82-d-old infant developed purpura at the same day after the second dose of oral polio vaccine. Until the time of hospital admission, the male infant had been in good health and had not received any drugs, and the possible causes of this condition were excluded. His platelet count was 13× 10 ( 9) /L. Platelet-associated IgG was elevated, but the amount of megakaryocytes in bone marrow aspirates was within the normal range, suggesting immune mechanism-associated thrombocytopenia. The infant recovered with the proper treatment within 30 d. Attention should be paid to OPV-associatedthrombocytopenia, though it seems to be less frequent than after natural infections.

Study Type : Human: Case Report

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